St. Louis #3 is located some 2 miles back from the French Quarter, some 30 blocks from the Mississippi, fronting Esplanade Avenue near Bayou St. John. It opened in 1854. The crypts on average are more elaborate than at the other St. Louis cemeteries, including a number of fine 19th century marble tombs. Those entombed include ragtime composer Paul Sarebresole and photographer E. J. Bellocq.
St. Louis #3 also includes a Greek Orthodox section. The cemetery was heavily flooded during the aftermath of Hurricane Katrina in 2005, but its tombs escaped relatively unscathed.